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Figure 2 | Cell Communication and Signaling

Figure 2

From: Oocyte activation and phospholipase C zeta (PLCζ): diagnostic and therapeutic implications for assisted reproductive technology

Figure 2

Schematic representation of the current understanding of PLCζ mechanism of action. Following sperm/oocyte fusion, PLCζ is released into the cytoplasm of the oocyte, where it facilitates the hydrolysis of membrane-bound PIP2 to DAG and IP3, triggering Ca2+ release from intracellular Ca2+ stores, leading to Ca2+ induced Ca2+ release and oocyte activation. The schematic illustrates the previous theory of PLCζ action upon membrane-bound PIP2, which is now being considered to be organelle-bound. N: Nucleus; PIP2: Phosphotidylinositol 4,5-bisphosphate; IP3: inositol trisphosphate; DAG: diacylglycerol; PKC: Protein kinase C; ER: Endoplasmic reticulum

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