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  1. Commentary

    Can erythrocytes release biologically active NO?

    Under physiological conditions, endothelial cells and the endothelial nitric oxide (NO) synthase (eNOS) are the main source of NO in the cardiovascular system. However, several other cell types have also been ...

    Peter M. Benz and Ingrid Fleming

    Cell Communication and Signaling 2016 14:22

    Published on: 17 September 2016

  2. Research

    Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets

    Vasodilator-Stimulated Phosphoprotein (VASP) is involved in the inhibition of agonist-induced platelet aggregation by cyclic nucleotides and the adhesion of platelets to the vascular wall. αIIbβ3 is the main inte...

    Peter M. Benz, Hebatullah Laban, Joana Zink, Lea Günther, Ulrich Walter, Stepan Gambaryan and Karim Dib

    Cell Communication and Signaling 2016 14:21

    Published on: 13 September 2016

  3. Review

    Interaction of MSC with tumor cells

    Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. imm...

    Catharina Melzer, Yuanyuan Yang and Ralf Hass

    Cell Communication and Signaling 2016 14:20

    Published on: 8 September 2016

  4. Research

    Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase

    Tyro3, Axl, and Mertk (TAMs) are a family of three conserved receptor tyrosine kinases that have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigene...

    Stanley G. Kimani, Sushil Kumar, Viralkumar Davra, Yun-Juan Chang, Canan Kasikara, Ke Geng, Wen-I Tsou, Shenyan Wang, Mainul Hoque, Andrej Boháč, Anita Lewis-Antes, Mariana S. De Lorenzo, Sergei V. Kotenko and Raymond B. Birge

    Cell Communication and Signaling 2016 14:19

    Published on: 6 September 2016

  5. Research

    Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling

    The phytoestrogen, genistein at low doses nongenomically activates mitogen-activated protein kinase p44/42 (MAPKp44/42) via estrogen receptor alpha (ERα) leading to proliferation of human uterine leiomyoma cells....

    Linda Yu, Kyle Ham, Xiaohua Gao, Lysandra Castro, Yitang Yan, Grace E. Kissling, Charles J. Tucker, Norris Flagler, Ray Dong, Trevor K. Archer and Darlene Dixon

    Cell Communication and Signaling 2016 14:18

    Published on: 31 August 2016

  6. Research

    A new mode of SAM domain mediated oligomerization observed in the CASKIN2 neuronal scaffolding protein

    CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASK...

    Ekaterina Smirnova, Jamie J. Kwan, Ryan Siu, Xin Gao, Georg Zoidl, Borries Demeler, Vivian Saridakis and Logan W. Donaldson

    Cell Communication and Signaling 2016 14:17

    Published on: 22 August 2016

  7. Research

    Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis

    Direct interaction between Red blood cells (RBCs) and platelets is known for a long time. The bleeding time is prolonged in anemic patients independent of their platelet count and could be corrected by transfu...

    Stepan Gambaryan, Hariharan Subramanian, Linda Kehrer, Igor Mindukshev, Julia Sudnitsyna, Cora Reiss, Natalia Rukoyatkina, Andreas Friebe, Iraida Sharina, Emil Martin and Ulrich Walter

    Cell Communication and Signaling 2016 14:16

    Published on: 11 August 2016

  8. Research

    Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin

    Canonical Wnt signals, transduced by stabilized β-catenin, play similar roles across animals in maintaining stem cell pluripotency, regulating cell differentiation, and instructing normal embryonic development...

    William Q. Gillis, Arif Kirmizitas, Yasuno Iwasaki, Dong-Hyuk Ki, Jonathan M. Wyrick and Gerald H. Thomsen

    Cell Communication and Signaling 2016 14:15

    Published on: 2 August 2016

  9. Research

    Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice

    The serine/threonine protein kinase C (PKC) theta has been firmly implicated in T cell-mediated immunity. Because its role in macrophages has remained undefined, we employed PKCtheta-deficient (PKCtheta ...

    Christa Pfeifhofer-Obermair, Karin Albrecht-Schgoer, Sebastian Peer, Manfred Nairz, Kerstin Siegmund, Victoria Klepsch, David Haschka, Nikolaus Thuille, Natascha Hermann-Kleiter, Thomas Gruber, Günter Weiss and Gottfried Baier

    Cell Communication and Signaling 2016 14:14

    Published on: 28 July 2016

  10. Research

    Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype

    Antigen (Ag)/IgE-mediated mast cell (MC) responses play detrimental roles in allergic diseases. MC activation via the high-affinity receptor for IgE (FcεRI) is controlled by the Src family kinase Lyn. Lyn-defi...

    Susana M. Nunes de Miranda, Thomas Wilhelm, Michael Huber and Carolin N. Zorn

    Cell Communication and Signaling 2016 14:12

    Published on: 20 May 2016

  11. Research

    The arabidopsis cyclic nucleotide interactome

    Cyclic nucleotides have been shown to play important signaling roles in many physiological processes in plants including photosynthesis and defence. Despite this, little is known about cyclic nucleotide-depend...

    Lara Donaldson, Stuart Meier and Christoph Gehring

    Cell Communication and Signaling 2016 14:10

    Published on: 11 May 2016

  12. Review

    The new (dis)order in RNA regulation

    RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism, from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be mostly mediated by canonical RN...

    Aino I. Järvelin, Marko Noerenberg, Ilan Davis and Alfredo Castello

    Cell Communication and Signaling 2016 14:9

    Published on: 6 April 2016

  13. Review

    Motif mediated protein-protein interactions as drug targets

    Protein-protein interactions (PPI) are involved in virtually every cellular process and thus represent an attractive target for therapeutic interventions. A significant number of protein interactions are frequ...

    Carles Corbi-Verge and Philip M. Kim

    Cell Communication and Signaling 2016 14:8

    Published on: 2 March 2016

  14. Short report

    Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

    Chronic myeloid leukemia (CML) is driven by the fusion kinase Bcr-Abl. Bcr-Abl tyrosine kinase inhibitors (TKIs), such as imatinib mesylate (IM), revolutionized CML therapy. Nevertheless, about 20 % of CMLs di...

    Sebastian Halbach, Zehan Hu, Christine Gretzmeier, Julia Ellermann, Franziska U. Wöhrle, Jörn Dengjel and Tilman Brummer

    Cell Communication and Signaling 2016 14:6

    Published on: 24 February 2016

  15. Research

    Feedback activation of neurofibromin terminates growth factor-induced Ras activation

    Growth factors induce a characteristically short-lived Ras activation in cells emerging from quiescence. Extensive work has shown that transient as opposed to sustained Ras activation is critical for the induc...

    Anne Hennig, Robby Markwart, Katharina Wolff, Katja Schubert, Yan Cui, Ian A. Prior, Manuel A. Esparza-Franco, Graham Ladds and Ignacio Rubio

    Cell Communication and Signaling 2016 14:5

    Published on: 9 February 2016

  16. Research

    Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells

    Cells of the tumor microenvironment are recognized as important determinants of the tumor biology. The adjacent non-malignant cells can regulate drug responses of the cancer cells by secreted paracrine factors...

    Svetlana Skolekova, Miroslava Matuskova, Martin Bohac, Lenka Toro, Erika Durinikova, Silvia Tyciakova, Lucia Demkova, Jan Gursky and Lucia Kucerova

    Cell Communication and Signaling 2016 14:4

    Published on: 12 January 2016

    The Erratum to this article has been published in Cell Communication and Signaling 2016 14:7

  17. Methodology

    MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry

    Human mesenchymal stromal cells (hMSC) are multipotent cells with both regenerative and immunomodulatory activities making them an attractive tool for cellular therapy. In the last few years it has been shown ...

    Teresa L. Ramos, Luis Ignacio Sánchez-Abarca, Sandra Muntión, Silvia Preciado, Noemí Puig, Guillermo López-Ruano, Ángel Hernández-Hernández, Alba Redondo, Rebeca Ortega, Concepción Rodríguez, Fermín Sánchez-Guijo and Consuelo del Cañizo

    Cell Communication and Signaling 2016 14:2

    Published on: 12 January 2016

  18. Review

    GPR91: expanding the frontiers of Krebs cycle intermediates

    Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. Mainly found in the mitochondrial matrix, some of the intermediates of the Krebs cycle are...

    Matheus de Castro Fonseca, Carla J. Aguiar, Joao Antônio da Rocha Franco, Rafael N. Gingold and M. Fatima Leite

    Cell Communication and Signaling 2016 14:3

    Published on: 12 January 2016

  19. Review

    Phase separation in biology; functional organization of a higher order

    Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded compartments and, within these, some are further organized into non-membrane-bounded structures termed membrane-less organelles. Th...

    Diana M. Mitrea and Richard W. Kriwacki

    Cell Communication and Signaling 2016 14:1

    Published on: 5 January 2016

  20. Review

    Short linear motifs – ex nihilo evolution of protein regulation

    Short sequence motifs are ubiquitous across the three major types of biomolecules: hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs and protein short linear motifs (SLiMs) ...

    Norman E. Davey, Martha S. Cyert and Alan M. Moses

    Cell Communication and Signaling 2015 13:43

    Published on: 21 November 2015

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